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This chapter addresses symmetry’s implications for expressive freedom and religious liberty. Symmetry supports maintaining First Amendment law’s current focus on neutrality, notwithstanding emerging critiques that this approach lacks a strong historical foundation and unduly limits governmental regulation of offensive or dangerous ideas. At the same time, symmetric interpretation counsels against expanding the emerging “First Amendment Lochnerism” that threatens to extend constitutional protections for free expression into areas of economic and workplace regulation. A preference for symmetry also supports protecting religious groups, when possible, through more general protections for freedom of expressive association rather than through religion-specific constitutional doctrines. Although religious liberty may once have been a symmetric principle, today religion-specific protections risk placing constitutional law on one side of a fraught political divide over religion’s place in public life.
The search for the causes of disease is an obvious central step in the pursuit of better health through disease prevention. In the previous chapters we looked at how we measure health (or disease) and how we look for associations between exposure and disease. Being able to identify a relation between a potential cause of disease and the disease itself is not enough, though. If our goal is to change practice or policy in order to improve health, then we need to go one step further and decide whether the relation is causal because, if it is not, intervening will have no effect. As in previous chapters, we discuss causation mainly in the context of an exposure causing disease but, as you will see when we come to assessing causation in practice, the concepts apply equally to a consideration of whether a potential preventive measure really does improve health.
This study aimed to evaluate the association between vegetable intake and major depressive disorder (MDD) through cross-sectional analysis and bidirectional two-sample Mendelian randomisation (MR).
Design:
Cross-sectional analysis was conducted on National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2018 and the corresponding Food Patterns Equivalents Database (FPED). Genome-wide association study (GWAS) data were obtained from UK Biobank and Psychiatric Genomics Consortium (PGC) dataset. Logistic regression analysis was performed after calculating the weights of the samples. Inverse variance weighted, MR-Egger and weighted median methods were used to evaluate the causal effects.
Setting:
A Patient Health Questionnaire-9 score ≥ 10 was considered to indicate MDD. Low vegetable intake was defined as < 2 cups of vegetables per day.
Participants:
30 861 U.S. adults from NHANES. The GWAS data sample size related to vegetable intake were comprised 448 651 and 435 435 cases respectively, while the GWAS data sample size associated with MDD encompassed 500 199 cases.
Results:
There were 23 249 (75·33 %) participants with low vegetable intake. The relationship between vegetable intake and MDD was nonlinear. In the multivariate model adjusted for sex, age, education, marital status, poverty income ratio, ethnicity and BMI, participants with low vegetable intake were associated with an increased risk of MDD (OR = 1·53, 95 % CI (1·32, 1·77), P < 0·001). Bidirectional MR showed no causal effects between vegetable intake and MDD.
Conclusions:
Cross-sectional analysis identified a significant relationship between vegetable intake and MDD, whereas the results from bidirectional two-sample MR did not support a causal role.
“Dream Defenders and the Inside Songs” explores the extent to which Percy Shelley's poetic legislation is able to counter racial divisiveness and antiBlackness in “our” communities and universities. It enlists Fred Moten’s poem “barbara lee” and Benjamin Zephaniah’s characterization of Shelley as the “original dub poet” to claim that what is “wholly political” about the semantic and sonic relays activated in Shelleyan songs is their capacity to disrupt the associational logics undergirding white-body supremacy and literary Anglo-Eurocentrism. Tracking the process enacted in “barbara lee,” by which reliance on “the inside songs” enables Representative Lee to vote against President Bush’s military authorization act, the chapter proposes some pedagogical and creative-critical revisions to Shelley studies that might effect a similar “inside outward opening” of Shelley. Leftist celebrations of “Red Shelley” have emphasized the collective and street-performative dimensions of his then-unpublished protest songs. The chapter probes the salience of a “black” Shelley by recasting two familiar Shelleyan devices. One emphasizes sound’s activation of embodied knowledge that circumvents the priority granted to textual literacy. A second accentuates association as a process that expands the affective-cognitive connections mobilized by a word and by encounters with another person. In other words, the intimacy between who we know and what we know is an underacknowledged fact of scholarly method. Diversifying one is key to diversifying the other in an ongoing cycle. Cultivating the two promises to transform “defenses” of poetry into live performances of antiracism.
Although some studies have examined the association between eating behaviour and elevated blood pressure (EBP) in adolescents, current data on the association between sugar-sweetened beverages (SSB) and EBP in adolescents in Yunnan Province, China, are lacking.
Setting:
Cluster sampling was used to survey freshmen at a college in Kunming, Yunnan Province, from November to December. Data on SSB consumption were collected using an FFQ measuring height, weight and blood pressure. A logistic regression model was used to analyse the association between SSB consumption and EBP, encompassing prehypertension and hypertension with sex-specific analyses.
Participants:
The analysis included 4781 college students.
Results:
Elevated systolic blood pressure (SBP) and diastolic blood pressure (DBP) were detected in 35·10 % (1678/4781) and 39·34 % (1881/4781) of patients, respectively. After adjusting for confounding variables, tea beverage consumption was associated with elevated SBP (OR = 1·24, 95 % CI: 1·03, 1·49, P = 0·024), and carbonated beverage (OR = 1·23, 95 % CI: 1·04, 1·45, P = 0·019) and milk beverage (OR = 0·81, 95 % CI: 0·69, 0·95, P = 0·010) consumption was associated with elevated DBP in college students. Moreover, fruit beverage (OR = 1·32, 95 % CI: 1·00, 1·75, P = 0·048) and milk beverage consumption (OR = 0·69, 95 % CI: 0·52, 0·93, P = 0·014) was associated with elevated DBP in males.
Conclusion:
Our findings indicated that fruit and milk beverage consumption was associated with elevated DBP in males, and no association was observed with EBP in females.
Bromley and Santos make a cultural argument that situates nonprofit organizations within the broader context of organization itself. Due to the ascendancy of organization as an emergent category of social structure, the authors suggest that all types of organizations (government, business, nonprofit) are becoming increasingly similar. As the divisions between them (e.g., for-profit organization vs. nonprofit organization, etc.) become less prominent, the sector in need of explanation is the organizational one, writ large. Thus, rather than explaining the nonprofit sector, per se, the authors argue that the nonprofit sector is just one manifestation of organization and that it is organization that deserves our attention. In this sense, sector theory as traditionally understood (as narrow attention to the nonprofit sector in comparison to other sectors) diverts attention from more fundamental sociocultural developments. The authors argue that one can only understand nonprofit organizations vis-à-vis government and for-profit organizations by first understanding this broader context.
Virtually all journal articles in the factor investing literature make associational claims, in denial of the causal content of factor models. Authors do not identify the causal graph consistent with the observed phenomenon, they justify their chosen model specification in terms of correlations, and they do not propose experiments for falsifying causal mechanisms. Absent a causal theory, their findings are likely false, due to rampant backtest overfitting and incorrect specification choices. This Element differentiates between type-A and type-B spurious claims, and explains how both types prevent factor investing from advancing beyond its current phenomenological stage. It analyzes the current state of causal confusion in the factor investing literature, and proposes solutions with the potential to transform factor investing into a truly scientific discipline. This title is also available as Open Access on Cambridge Core.
The two dominant conceptions of political economy are based on either reducing political decisions to rational-choice reasoning or, conversely, reducing economic structures and phenomena to the realm of politics. In this book, Adrian Pabst and Roberto Scazzieri contend that neither conception is convincing and argue for a fundamental rethinking of political economy. Developing a new approach at the interface of economic theory and political thought, the book shows that political economy covers a plurality of dimensions, which reflect internal hierarchies and multiple relationships within the economic and political sphere. The Constitution of Political Economy presents a new, richer conception of political economy that draws on a range of thinkers from the history of political economy, recognising the complex embedding of the economy and the polity in society. Effective policy-making has to reflect this embedding and rests on the interdependence between local, national, and international actors to address multiple systemic crises.
Edited by
Deepak Cyril D'Souza, Staff Psychiatrist, VA Connecticut Healthcare System; Professor of Psychiatry, Yale University School of Medicine,David Castle, University of Tasmania, Australia,Sir Robin Murray, Honorary Consultant Psychiatrist, Psychosis Service at the South London and Maudsley NHS Trust; Professor of Psychiatric Research at the Institute of Psychiatry
Does cannabis use play a causal role in subsequent violence? The available research suggests an association between cannabis use and risk of being a perpetrator of violence. Indeed, cannabis users are at increased risk of carrying out severe violence, including aggravated assault, sexual aggression, fighting, and robbery. There is also evidence on the association between cannabis use and subsequent victimization (e.g., intimate partner violence). Individuals with severe mental disorders also show an incremented risk of violence, considering their higher rate of cannabis use compared to the general population. Possible mechanisms underlying this association involve (1) the neurobiological effect of the substance after acute use, but also during abstinence and withdrawal, and (2) social factors, such as the violent/criminal lifestyles of cannabis users. However, it is important to acknowledge the limitations of the current literature. Most available studies are cross-sectional and retrospective, so it remains difficult to disentangle the direction of the association. Despite that, cannabis use may be a useful preventive intervention target, particularly among at-risk groups such as psychiatric patients.
Measuring and quantifying dependencies between random variables (RVs) can give critical insights into a dataset. Typical questions are: ‘Do underlying relationships exist?’, ‘Are some variables redundant?’, and ‘Is some target variable Y highly or weakly dependent on variable X?’ Interestingly, despite the evident need for a general-purpose measure of dependency between RVs, common practice is that most data analysts use the Pearson correlation coefficient to quantify dependence between RVs, while it is recognized that the correlation coefficient is essentially a measure for linear dependency only. Although many attempts have been made to define more generic dependency measures, there is no consensus yet on a standard, general-purpose dependency function. In fact, several ideal properties of a dependency function have been proposed, but without much argumentation. Motivated by this, we discuss and revise the list of desired properties and propose a new dependency function that meets all these requirements. This general-purpose dependency function provides data analysts with a powerful means to quantify the level of dependence between variables. To this end, we also provide Python code to determine the dependency function for use in practice.
Individuals avoid objects that have been in physical contact with morally offensive or disgusting entities. This has been called negative magical contagion, an implicit belief in the transmission of essence by physical contact. Alternatively, individuals may avoid a negatively contaminated object because: 1) the object is a strong reminder of the original contagion source (association account); or 2) the act of interacting with the object signals specific information about the self (social communication account). We report that: 1) people often prefer to interact with an entity that they believe is more associated with a negative source rather than an entity that is less associated but has made physical contact with the same negative source; 2) while an associative account requires that contact enhances association, a study of memory for visual pairings of objects indicates that when objects are touching, their associative link (recall) is no greater than when they are in proximity; and 3) subjects continue to show aversion to (prefer to wear gloves to handle) an object that contacted a negative entity even if they are handling the object in order to physically destroy it, hence strongly signaling their rejection of that object. Association and social communication are at best partial accounts for contagion effects.
Copy number variation (CNV) is a very common type of gene variation with high frequency. In recent years, CNV has been paid more attention in various fields, especially in livestock and poultry breeding, which has promoted the progress of breeding. WW domain binding protein 1-like (WBP1L) is a protein coding gene, which plays an important role in cattle populations, and its function has been extensively studied, but it is not clear whether the copy number of the gene can affect the growth and development of cattle populations. In this study, CNV of WBP1L gene was detected in 732 cattle of seven breeds (Qinchuan cattle, QC; Pinan cattle, PN; Yuengling cattle, YL; Xianan cattle, XN; Jiaxian cattle, JX; natural Guyuan cattle, NGY; Jian cattle, JA). In addition, the relationship between CNV and growth phenotype of cattle was studied. The experimental data indicate that the copy number of WBP1L was obviously correlated with heart girth of PN cattle (**P < 0.01), rump length (RL) and body weight (BW) of PN cattle (*P < 0.05), withers height (WH), RL, body length, chest depth and BW of JX cattle (*P < 0.05), WH of NGY cattle (*P < 0.05) and WH of JA cattle (*P < 0.05). It was proved that CNV of WBP1L gene could be used as molecular marker locus for genetic breeding of the above four cattle breeds.
To validate the two-factor structure (i.e., cognitive and somatic) of the Health and Behaviour Inventory (HBI), a widely used post-concussive symptom (PCS) rating scale, through factor analyses using bifactor and correlated factor models and by examining measurement invariance (MI).
Methods:
PCS ratings were obtained from children aged 8–16.99 years, who presented to the emergency department with concussion (n = 565) or orthopedic injury (OI) (n = 289), and their parents, at 10-days, 3-months, and 6-months post-injury. Item-level HBI ratings were analyzed separately for parents and children using exploratory and confirmatory factor analyses (CFAs). Bifactor and correlated models were compared using various fit indices and tested for MI across time post-injury, raters (parent vs. child), and groups (concussion vs. OI).
Results:
CFAs showed good fit for both a three-factor bifactor model, consisting of a general factor with two subfactors (i.e., cognitive and somatic), and a correlated two-factor model with cognitive and somatic factors, at all time points for both raters. Some results suggested the possibility of a third factor involving fatigue. All models demonstrated strict invariance across raters and time. Group comparisons showed at least strong or strict invariance.
Conclusions:
The findings support the two symptom dimensions measured by the HBI. The three-factor bifactor model showed the best fit, suggesting that ratings on the HBI also can be captured by a general factor. Both correlated and bifactor models showed substantial MI. The results provide further validation of the HBI, supporting its use in childhood concussion research and clinical practice.
Turning to more ceremonial, less habitual actions in which a young heir’s active participation could be vital, this chapter stresses the political community’s wider investment in children as political actors. Royal children were both enablers and facilitators of diplomacy rather than merely pawns in the diplomatic and political games of adults. Children’s participation could be decisive to acts of association and diplomacy, and thus vital to readying the realm for their succession and rule. The chapter first examines attempts to secure magnate loyalty to children through oaths of fidelity and performances of homage. The earliest stages of the male life cycle had unique attributes in regard to demonstrations of loyalty, and there were substantial benefits in securing oaths to children when they were so young. The chapter then turns to focus on children’s incorporation within performances of cross-kingdom diplomacy, an important aspect of children’s education. The final section foregrounds the chanson de geste Le couronnement de Louis to examine the importance of children’s dynamic contribution at coronation and the wider political community’s investment in boy kings.
This chapter considers the relationship between antitrust law and the First Amendment as those topics relate to workers’ collective action. It asks why the US Supreme Court has remained unwilling to accept First Amendment defenses in cases involving potential antitrust liability for strikes and boycotts, even as it has expanded the scope of First Amendment protections available in analogous situations. The chapter begins by reviewing foundational cases regarding antitrust liability for strikes and boycotts. It then discusses subsequent developments in First Amendment doctrine related to commercial speech, free association, and civil-rights boycotts. Finally, the chapter turns to the 1990 US Supreme Court case, Federal Trade Commission v. Superior Court Trial Lawyers Association, showing how First Amendment principles that are uncontroversial in other contexts could have driven a different outcome. The chapter closes with observations about the modern Supreme Court’s views of the purposes of the First Amendment, and difficulties workers and unions are likely to encounter thereunder.
Certain universal and more or less perennial aspects of human perceptions of the night influence the representation of nightlife in ancient texts. But beyond the stereotypes, we may recognize tensions between conservative perceptions and a continually changing reality. In the Roman empire, we may observe certain recurring elements of a ‘nocturnal koine’, the result of general trends. The factors that shaped nightlife in the Roman empire include the diffusion of voluntary associations and their convivial activities, the donations of benefactors for nighttime activities (baths, gymnasia, public banquets), the prominent place of nocturnal rites in cults with a soteriological or initiatory aspect, and efforts to increase the safety in cities during the night. These factors should be considered within a broader context—that of the gradual and continuous colonization of the night with the activities of the day.
This chapter describes and analyzes how British pluralists in the early twentieth century critiqued the fusion of nationality and statehood that had hitherto provided a conceptual foundation for political science, and how their critique exposed the discipline to the problem of social order. The chapter also treats the contemporary critical reception of British pluralism in America.
Young adulthood is a crucial period for major physiological transitions. Environmental changes associated with these transitions can influence health behaviour and health (e.g. poor diet, high body weight and elevated blood pressure (EBP)). Excess body weight can lead to EBP; however, little is known about this relationship among young adults in developing countries. Focusing on Bangladesh, this study assessed the association between BMI and blood pressure (BP) metrics (systolic BP (SBP), diastolic BP (DBP) and BP class (optimal, normal/high normal and elevated)). Sex-specific analyses of these relationships were performed to assess any difference across sexes. Furthermore, associations of overweight/obesity with BP metrics were investigated. Young adults aged 18–24 years (n 2181) were included from nationally representative cross-sectional Bangladesh Demographic and Health Survey 2017–2018. Multivariable linear and multinomial logistic regression models examined the relationships between BMI, overweight/obesity and BP metrics. Findings reveal that higher BMI was associated with higher SBP (0·83; 95 % CI 0·67, 0·99), DBP (0·66; 95 % CI 0·54, 0·74) and higher odds of having EBP (adjusted OR 1·24; 95 % CI 1·17, 1·31). These relationships were stronger among males than females. Moreover, overweight/obese individuals had higher SBP, DBP and higher odds of having EBP than individuals with normal BMI. Strategies to reduce body weight and to improve healthy lifestyle, and awareness and monitoring of BP may help to address these serious health problems, particularly at an early age.
Meeting the complex demands of conservation requires a multi-skilled workforce operating in a sector that is respected and supported. Although professionalization of conservation is widely seen as desirable, there is no consistent understanding of what that entails. Here, we review whether and how eight elements of professionalization observed in other sectors are applicable to conservation: (1) a defined and respected occupation; (2) official recognition; (3) knowledge, learning, competences and standards; (4) paid employment; (5) codes of conduct and ethics; (6) individual commitment; (7) organizational capacity; and (8) professional associations. Despite significant achievements in many of these areas, overall progress is patchy, and conventional concepts of professionalization are not always a good fit for conservation. Reasons for this include the multidisciplinary nature of conservation work, the disproportionate influence of elite groups on the development and direction of the profession, and under-representation of field practitioners and of Indigenous peoples and local communities with professional-equivalent skills. We propose a more inclusive approach to professionalization that reflects the full range of practitioners in the sector and the need for increased recognition in countries and regions of high biodiversity. We offer a new definition that characterizes conservation professionals as practitioners who act as essential links between conservation action and conservation knowledge and policy, and provide seven recommendations for building a more effective, inclusive and representative profession.
Americans know the story of democracy: how the Framers built a government with branches that would check and balance, that would derive its authority from sovereign citizens, filtered and refined by their elected representatives. Americans may refer to our system as “democracy” but the representative republican framework provided by the Framers ensured the safe democratization of our country over time. This well-rehearsed story frames American democracy as a bequest from the Framers. Yet this powerful founding story is a victor’s tale, designed to erase from collective historical memory a very real battle with a robust alternative model of democratic theory and practice that was flourishing – much to the Framers’ consternation – in the early nation. This alternative democracy originated in the daily practices of ordinary colonists. Their vernacular democracy generated and motored revolution; and though the political elite embraced this participatory and equalitarian practice, they later pulled away, seeking in their words to “tame” the democratic enthusiasm and power of ordinary American citizens even as they drew on that power (renamed “sovereignty”) to authorize the representative federal republicanism they offered as a containment device. Knowing about vernacular democracy enables readers to see its record in the literature of the early United States.