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Multilingual language control is commonly investigated using picture-naming paradigms with explicit instructions when to switch between languages. In daily life, language switching also occurs without external cues. Cued language-switching tasks usually show a switch cost (i.e., slower responses on switch than non-switch trials). Findings of switch costs in response times are mixed for voluntary language switching. This pre-registered study uses a bilingual picture-naming paradigm to compare voluntary and cued language switching in 25 highly proficient Dutch-English bilinguals using EEG. We analysed the N2 ERP component and midfrontal theta oscillations, two common electrophysiological markers of cognitive control in task and language switching. We observed significantly smaller behavioural switch costs in the voluntary task. This suggests that voluntary language switching is less effortful than switching based on external cues. However, we found no electrophysiological switch effects in either task. We discuss factors which may contribute to the inconsistency between behavioural and electrophysiological findings.
The fact that opioids constrict the pupil is known to healthcare workers and the lay public. In this chapter, the mechanism of this effect is discussed and how an understanding of this mechanism can be useful to the clinician. There are many parameters that can be measured from the pupil with portable pupillometers. The measure that most closely predicts the onset of severe respiratory depression is pupillary unrest in ambient light (PUAL). This measure is compared to pupil size and pupillary constriction amplitude as a measure of toxic levels of opioids.
The brain stem center that controls the pupillary light reflex is activated by light. This center is called the Edinger-Westphal (EW) nucleus, and it has excitatory synaptic input from the pretectal nucleus. The EW nucleus also receives inhibitory input that depresses activity in those neurons and dilates the pupil. The inhibitory influences projecting to the EW nucleus are discussed in this chapter
Psycholinguistic theories conceptualize the mind as a set of mechanical processes that map between levels of mental representation. Cognition is seen as a form of computation, emerging from the interaction of these processes. We explore how this conceptualization frames psycholinguistic research questions. We first examine how the idea of “mind as computer” leads psycholinguists to examine two broad types of questions. Some studies focus on the structure of mental representations (e.g., are “similar” speech sounds associated with one vs. two representations across languages?). Others focus on the number and nature of processes underlying behavior (e.g., to what extent do speech perception and speech production rely on distinct vs. shared processes?). We then turn to connectionism, a specific computational framework that has dominated psycholinguistic theories of bilingualism. Connectionism’s conceptualization of processing as spreading activation has driven studies of representation and processing. We conclude by considering how psycholinguistic theories can inform as well as be informed by other perspectives
This study aimed to delineate profiles of self-regulation among sexually abused children and their association with behavior problems using a person-centered approach. A sample of 223 children aged six to 12, their parents, and teachers were recruited in specialized intervention centers. Latent profile analysis revealed four profiles: (1) Dysregulated, (2) Inhibited, (3) Flexibly Regulated, and (4) Parent Perceived Self-Regulation. Children from the Flexibly Regulated profile showed relatively low behavior problems, and those from the Dysregulated profile were characterized by high behavior problems. Children from the Parent Perceived Self-Regulation profile showed overall good adaptation, although teachers reported higher behavior problems than parents. Children from the Inhibited profile, characterized by the highest level of inhibition but low parent-rated emotion regulation competencies and executive functions, showed the highest level of internalizing behavior problems, indicating that high inhibition does not necessarily translate to better adaptation. Results also show a moderation effect of sex. Being assigned to the Inhibited profile was associated with decreased externalizing behaviors in boys and increased internalizing behaviors in girls. This study underscores the complexity of self-regulation in sexually abused children and supports the need to adopt a multi-method and multi-informant approach when assessing these children.
A broad and extensive literature has investigated the cognitive consequences of bilingualism on cognitive control. Results from these studies, while controversial, support the conclusion that speaking a second language confers non-linguistic benefits. Whether other related linguistic experiences, such as dialect use, confer similar benefits remains an underexplored and open question. The common use of a diverse range of local dialects across China provides ideal conditions under which to explore this question. Using a dialectally heterogeneous sample of Mandarin-English bilingual young adults (n = 74), the present study investigated whether differences in dialect proficiency impacted on inhibition and attentional control while accounting for variation in language experience. Dialect proficiency was not associated with improved performance on the Simon task, Attention Network Test, or Flanker task, suggesting no benefits in inhibition or attentional control. Considerations for future studies investigating the influence of Chinese dialect experience on cognitive control are discussed.
We consider a Poisson autoregressive process whose parameters depend on the past of the trajectory. We allow these parameters to take negative values, modelling inhibition. More precisely, the model is the stochastic process $(X_n)_{n\ge0}$ with parameters $a_1,\ldots,a_p \in \mathbb{R}$, $p\in\mathbb{N}$, and $\lambda \ge 0$, such that, for all $n\ge p$, conditioned on $X_0,\ldots,X_{n-1}$, $X_n$ is Poisson distributed with parameter $(a_1 X_{n-1} + \cdots + a_p X_{n-p} + \lambda)_+$. This process can be regarded as a discrete-time Hawkes process with inhibition and a memory of length p. In this paper we initiate the study of necessary and sufficient conditions of stability for these processes, which seems to be a hard problem in general. We consider specifically the case $p = 2$, for which we are able to classify the asymptotic behavior of the process for the whole range of parameters, except for boundary cases. In particular, we show that the process remains stochastically bounded whenever the solution to the linear recurrence equation $x_n = a_1x_{n-1} + a_2x_{n-2} + \lambda$ remains bounded, but the converse is not true. Furthermore, the criterion for stochastic boundedness is not symmetric in $a_1$ and $a_2$, in contrast to the case of non-negative parameters, illustrating the complex effects of inhibition.
Numerous studies have shown a decrease in executive functions (EF) associated with aging. However, few investigations examined whether this decrease is similar between sexes throughout adulthood. The present study investigated if age-related decline in EF differs between men and women from early to late adulthood.
Methods:
A total of 302 participants (181 women) aged between 18 and 78 years old completed four computer-based cognitive tasks at home: an arrow-based Flanker task, a letter-based Visual search task, the Trail Making Test, and the Corsi task. These tasks measured inhibition, attention, cognitive flexibility, and working memory, respectively. To investigate the potential effects of age, sex, and their interaction on specific EF and a global EF score, we divided the sample population into five age groups (i.e., 18–30, 31–44, 45–54, 55–64, 65–78) and conducted analyses of covariance (MANCOVA and ANCOVA) with education and pointing device as control variables.
Results:
Sex did not significantly affect EF performance across age groups. However, in every task, participants from the three youngest groups (< 55 y/o) outperformed the ones from the two oldest. Results from the global score also suggest that an EF decrease is distinctly noticeable from 55 years old onward.
Conclusion:
Our results suggest that age-related decline in EF, including inhibition, attention, cognitive flexibility, and working memory, becomes apparent around the age of 55 and does not differ between sexes at any age. This study provides additional data regarding the effects of age and sex on EF across adulthood, filling a significant gap in the existing literature.
In Chapter 5, we discuss the processing components that underlie the perspective-taking analogy that we articulated in Chapter 2. This analysis makes it clear that the retrieval of personal knowledge and experience is critical, and we review some of what is known about episodic retrieval and how it can be used in this context. In forming an analogy, one must be able to identify how elements of the story world are related to corresponding elements in one’s own experience. To understand this process, we discuss how readers must construct similarity relations. Finally, we discuss the mechanics of analogy formation per se and describe the notion of a structural mapping between the reader and the character that underlies the perspective-taking analogy. We close out Chapter 5 with a discussion of perspective-taking dynamics. This includes an illustration of how perspective taking can be driven by the events of the story world or evaluations of the character. As we make clear, perspective taking is an ongoing process that can unfold in a variety of ways over the course of reading a narrative.
There is accumulating evidence that distinct forms of domain-general inhibition underlie the selection of lexical candidates from among co-activated representations in single-word production. It is less clear whether similar control processes are engaged in the resolution of syntactic conflict in sentence production. This study assessed the relative contribution of three types of inhibitory control operating at different stages of information processing to syntactic interference resolution in an active-passive voice production task. Inhibition of response execution (the anti-saccade effect) and resolution of representational conflict (the flanker effect) were related to the occurrence of repairs and sentence onset latencies in passive voice trials. The results suggest not only that general-purpose mechanisms may be in place that resolve conflict regardless of whether it stems from syntactic or non-syntactic (non-verbal) representations, but also that they operate at dissociable processing stages.
Curiosity and creativity are central pillars of human growth and invention. Although they have been studied extensively in isolation, the relationship between them has not yet been established. We propose that both curiosity and creativity emanate from the same mechanism of novelty seeking. We first present a synthesis showing that curiosity and creativity are affected similarly by a number of key cognitive faculties such as memory, cognitive control, attention, and reward. We then review empirical evidence from neuroscience research, indicating that the same brain regions are involved in both curiosity and creativity, focusing on the interplay between three major brain networks: the default mode network, the salience network, and the executive control network. After substantiating the link between curiosity and creativity, we propose a novelty-seeking model (NSM) that underlies them and suggests that the manifestation of the NSM is governed by one's state of mind.
This study investigated the engagement of domain-general cognitive control during the comprehension of dense code-switching sentences. Stimulus-locked event-related potentials (ERPs) were measured while L1-dominant Chinese–English bilinguals read switch and non-switch sentences. The results of the reading task revealed language dominance effects on the N400, left anterior negativity (LAN) and late positive component (LPC). The language dominance effects at lexical level (i.e., on the N400 and LAN) were modulated by individual differences in monitoring capacity. In contrast, inhibition capacity predicted code-switching costs at the sentence level (i.e., for the LPC component). The results suggest that proactive monitoring and reactive inhibition affect different processing stages during the comprehension of dense code-switching sentences. These findings partially align with processing models of code-switching incorporating a dual control mode perspective and contribute new insight into the dynamic interplay between reactive and proactive control processes.
The developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation associated with risk for a range of neuropsychological difficulties. Inhibitory control outcomes, including interference control and response inhibition, in children with AgCC are unclear. This study examined interference control and response inhibition: 1) in children with AgCC compared with typically developing (TD) children, 2) in children with different anatomical features of AgCC (complete vs. partial, isolated vs. complex), and 3) associations with white matter volume and microstructure of the anterior (AC) and posterior commissures (PC) and any remnant corpus callosum (CC).
Methods:
Participants were 27 children with AgCC and 32 TD children 8–16 years who completed inhibitory control assessments and brain MRI to define AgCC anatomical features and measure white matter volume and microstructure.
Results:
The AgCC cohort had poorer performance and higher rates of below average performance on inhibitory control measures than TD children. Children with complex AgCC had poorer response inhibition performance than children with isolated AgCC. While not statistically significant, there were select medium to large effect sizes for better inhibitory control associated with greater volume and microstructure of the AC and PC, and with reduced volume and microstructure of the remnant CC in partial AgCC.
Conclusions:
This study provides evidence of inhibitory control difficulties in children with AgCC. While the sample was small, the study found preliminary evidence that the AC (f2=.18) and PC (f2=.30) may play a compensatory role for inhibitory control outcomes in the absence of the CC.
The present study investigates current proposals that priming is a mechanism of cross-linguistic influence (CLI) in bilinguals by aiming to boost CLI through priming. In two cross-linguistic structural priming experiments with less-proficient adolescent (Study 1) and more highly proficient adult German-English learners (Study 2), we assess whether structural priming enhances CLI for well-formed, dispreferred, and ungrammatical structures. L2 learners in both studies showed CLI in their production, in particular for structures with word order overlap. They also exhibited short-term cross-linguistic priming of grammatical L1-L2 word orders in L2 English, which extended to longer-term priming among the more highly proficient learners in Study 2. However, there was no evidence that cross-linguistic priming increased the use of dispreferred or ungrammatical L1-based word orders in L2 English in either study. Rather, the overall production of these word orders decreased. Together, these results suggest that, while cross-linguistic priming leads learners to increase the use of shared, grammatical L1-L2 word orders, it leads to the inhibition of non-shared ungrammatical structures in L2 production. We conclude that priming has asymmetrical effects on CLI of grammatical and ungrammatical L1-based structures in the L2.
Cognitive control refers to our ability to regulate thoughts and actions for adaptive, goal-directed behaviors. Traditionally, cognitive control is thought to be mediated by the prefrontal cortex; however, the thalamus likely plays an important yet underappreciated role. This chapter reviews the role of the human thalamus in cognitive control. We first review anatomical, human functional neuroimaging, and human neuropsychology findings that have investigated the role of the human thalamus in two cognitive control functions: working memory and top-down biasing. To understand how the human thalamus mechanistically supports cognitive control, we then summarize operational principles of thalamocortical circuits from anatomical and neurophysiological studies. Finally, we present an overarching conceptual framework to describe how thalamocortical circuits implement different components of information processing necessary for cognitive control. In conclusion, we refute the traditional view that the thalamus passively relays signals to the cortex for purposeful processing. Instead, emerging evidence suggests that the thalamus actively modulates cortical activity and cortical network interactions to shape and coordinate information processes underlying cognitive control.
Inhibitory control is the executive function component which underlies one’s ability to maintain goal-directed behavior by inhibiting prepotent responses or ignoring irrelevant information. Recent models suggest that impaired inhibition of negative information may contribute to depressive symptoms, and that this association is mediated by rumination. However, the exact nature of this association, particularly in non-clinical samples, is unclear.
Objectives
The goal of the current study was to assess the relationship between inhibitory control over emotional vs. non-emotional information, rumination and depressive symptoms.
Methods
A non-clinical sample of 119 participants (mean age: 36.44 ± 11.74) with various levels of depressive symptoms completed three variations of a Go/No-Go task online; two of the task variations required either explicit or implicit processing of emotional expressions, and a third variation contained no emotional expressions (i.e., neutral condition).
Results
We found that for participants who reported elevated depressive symptoms, their inhibitory control ability was reduced for all three task variations, relative to less depressed participants. However, for the task variation that required implicit emotion processing (rather than explicit), depressive symptoms were associated with inhibitory deficits for sad and neutral, but not for happy facial expressions. An exploratory analysis showed that the relationship between inhibition and depressive symptoms occurs in part through trait rumination for all three tasks, regardless of emotional content.
Conclusions
Collectively, these results indicate that elevated depressive symptoms are associated with both a general inhibitory control deficit, as well as affective interference from negative emotions, with implications for the assessment and treatment of mood disorders.
In recent years, physical activity as a potential intervention for attention-deficit hyperactivity disorder (ADHD) became into the focus of researchers, however the results are conflicting.
Objectives
Our aim was to investigate the effect of acute moderate physical activity on executive functions requiring inhibition.
Methods
The study included 50 treatment-naïve ADHD children, 50 medicated children with ADHD and 50 typically developing children, aged 6–12 years. To diagnose ADHD, we applied the Mini International Neuropsychiatric Interview for Children and Adolescents. To measure executive functions, the pediatric version of the Test of Attentional Performance (KiTAP) was used. Half of the children in each study group participated in a 20-minute, moderately intense exercise while watching a cartoon video. In the control intervention, the other half of the children from all three study groups watched the same cartoon video in a sitting position for 20 min.
Results
Regarding distractibility, flexibility and inhibition, physical activity had a significant positive effect on two of 10 parameters (number of total errors and errors when distractor was presented, both in the distractibility task) in the treatment-naïve ADHD group.
Conclusions
Our results suggest that moderate acute physical activity has some significant positive effects on certain executive function parameters among children with ADHD. Future studies should consider determining the optimal form, intensity, and duration of physical activity to become a potential adjunctive intervention for children diagnosed with ADHD.
Language contact studies and historical linguistics, i.e. the study of language change, are subfields of linguistics that have long been recognized as being mutually relevant. This chapter explores this relationship along two dimensions: first, with regard to the fields of study themselves, and second, and perhaps more importantly, with regard to those aspects of language contact and of influence external to a given linguistic system that are particularly relevant to understanding the basic subject matter of historical linguistics, i.e. what happens to languages as they pass through time. In terms of the fields of study, an overview of the historiography of the distinction between internally motivated and externally motivated change is offered. This survey is followed by a discussion of several case studies, in which language contact serves as an actuator of change as well as some in which it is an inhibitor of change. Finally, the interaction of language contact with another key issue in historical linguistics, namely language genealogy, is discussed, along with a consideration of the naturalness and pervasiveness of language contact.
Leishmania spp. are parasitic protozoa that cause leishmaniasis, a disease endemic in 98 countries. Leishmania promastigotes are transmitted by the vector and differentiate into amastigotes within phagocytic cells of the vertebrate host. To survive in multiple and hostile environments, the parasite has several virulence factors. Oligopeptidase B (OPB) is a serine peptidase present in prokaryotes, some eukaryotes and some higher plants. It has been considered a virulence factor in trypanosomatids, but only a few studies, performed with Old World species, analysed its role in Leishmania virulence or infectivity.
L. (L.) amazonensis is an important agent of cutaneous leishmaniasis in Brazil. The L. (L.) amazonensis OPB encoding gene has been sequenced and analysed in silico but has never been expressed. In this work, we produced recombinant L. (L.) amazonensis OPB and showed that its pH preferences, Km and inhibition patterns are similar to those reported for L. (L.) major and L. (L.) donovani OPBs. Since Leishmania is known to secrete OPB, we performed in vitro infection assays using the recombinant enzyme. Our results showed that active OPB increased in vitro infection by L. (L.) amazonensis when present before and throughout infection. Our findings suggest that OPB is relevant to L. (L.) amazonensis infection, and that potential drugs acting through OPB will probably be effective for Old and New World Leishmania species. OPB inhibitors may eventually be explored for leishmaniasis chemotherapy.
This study investigated whether the deployment of cognitive control was modulated by the intra-sentential code-switching types during comprehension. L1-dominant Chinese–English bilinguals were administered a self-paced reading task in two reading contexts – namely, alternation context and dense code-switching context. We assessed language switch cost and reversed language dominance effect in the self-paced reading task and examined how these language control measures related to domain-general inhibition and monitoring capacities. The results showed a larger switch cost asymmetry in alternation context compared to dense CS context. In addition, bilinguals’ inhibition skills were associated with second language (L2) switch cost in alternation context, while monitoring tended to predict the language dominance effect in dense code-switching context. These findings suggest that alternation context exerts high requirement to reactive inhibition while dense code-switching context tends to induce proactive monitoring during comprehension. We conclude that intra-sentential code-switching types trigger different aspects of cognitive control during comprehension.