Premodern medicine used a variety of mineral substances for therapeutic purposes. The present article deals with pitch-asphalt, and, in particular, a precious kind of it called mūmiyāʾ originating in Persia. It was first described in detail in the Arabic pharmacological tradition, and its fame spread throughout the medieval Mediterranean, including Byzantium. By editing and examining for the first time a previously unexplored medieval Greek text on mūmiyāʾ, this study offers new insights into the medicinal uses of this substance. It also significantly increases our understanding of the intense cross-cultural transfer of medical knowledge from the Islamicate world to Byzantium by showing that this was not merely based on the translation of a few Arabic medical works into Greek, but was a multifaceted phenomenon involving a complex nexus of sources that require further investigation.

Essential minerals are cofactors for synthesis of neurotransmitters supporting cognition and mood. An 8-week fully-blind randomised controlled trial of multinutrients for attention-deficit/hyperactivity disorder (ADHD) demonstrated three times as many children (age 6–12) had significantly improved behaviour (‘treatment responders’) on multinutrients (54 %) compared with placebo (18 %). The aim of this secondary study was to evaluate changes in fasted plasma and urinary mineral concentrations following the intervention and their role as mediators and moderators of treatment response. Fourteen essential or trace minerals were measured in plasma and/or urine at baseline and week eight from eighty-six participants (forty-nine multinutrients, thirty-seven placebos). Two-sample t tests/Mann–Whitney U tests compared 8-week change between treatment and placebo groups, which were also evaluated as potential mediators. Baseline levels were evaluated as potential moderators, using logistic regression models with clinical treatment response as the outcome. After 8 weeks, plasma boron, Cr (in females only), Li, Mo, Se and vanadium and urinary iodine, Li and Se increased more with multinutrients than placebo, while plasma phosphorus decreased. These changes did not mediate treatment response. However, baseline urinary Li trended towards moderation: participants with lower baseline urinary Li were more likely to respond to multinutrients (P = 0·058). Additionally, participants with higher baseline Fe were more likely to be treatment responders regardless of the treatment group (P = 0·036.) These results show that multinutrient treatment response among children with ADHD is independent of their baseline plasma mineral levels, while baseline urinary Li levels show potential as a non-invasive biomarker of treatment response requiring further study.

Mineralizable macronutrients (e.g. C, N, P, and S) are sorbed readily (i.e. adsorption and precipitation) in clays and clay minerals. Phosphorus (P) is one of the limiting macronutrients in soils because both phosphate and organic P undergo chemisorption in soil minerals. Furthermore, phosphatases that mineralize the organic P species tend to partition into soil minerals, suppressing the interactions between organic P and phosphatase. Adsorbed phosphatase on the mineral surfaces can regulate the enzyme activity and influence the biochemical properties of the enzyme (e.g. kinetics, conformation, and stability), affecting the P cycle in the terrestrial environment. Phosphatase–mineral interactions are widely reported to decrease the enzyme activity while enhancing the enzyme stability (e.g. thermal and proteolysis stability). Contradictory findings have also been reported. Specific enzymes, mineral characteristics, and reaction conditions are probably responsible for various reactivity (e.g. mineralization). The purpose of the present review was to summarize current and past investigations of acid and alkaline phosphatase sorption in clays and clay minerals and to examine phosphatase chemical properties (e.g. kinetic activity, thermal and proteolysis stability) and factors (e.g. pH, saturating cations of the mineral, enzyme structure, and mineral surface polarity) influencing the phosphatase-mineral interaction. Lastly, also reviewed is the application of phosphatase–mineral interactions with some expansion to other enzymes as an indication of potential future application for phosphatase and future research needs.

Clays and their composites have been widely used for secondary containment walls for underground storage tanks and landfills. The pore-size changes occurring in the clay have a profound effect on its permeability. This study presents a new method for evaluating the use of an atomic force microscope (AFM) for studying wet clay in a non-aqueous state in order to determine the pore-size of clay at various water contents, a type of study typically performed by the more expensive environmental scanning electronic microscope. The method consists of mounting a sponge saturated with water under the sample in order to prevent drying by the heat generated by the AFM electronics. The micro-scale AFM image results show that the clay-particle separations reduce linearly as the water content increases. This change in pore-size is postulated to be attributed to the reduction in the size of the diffuse double layer and more extensive hydrogen bonds between clay particles and bipolar water molecules. The AFM was not able to produce nano-scale images due to excessive adhesion between the cantilever arm and the wet clay sample.

Several procedures for hydrothermal synthesis of saponite can be found in the literature. They differ in terms of the preparation conditions of the precursor and of the synthesis temperature. The objective of the present study was to investigate how these two parameters influence the structure of the final synthesis product. The precursor was prepared from Mg(NO3)2, Al(NO3)3, and Na4SiO4 in three different ways: as a gel, a dried gel, and a calcined gel. The influence of the synthesis temperature on the structure of saponite was investigated in the range 90–200°C. The results showed that the use of a calcined precursor yielded a single mineral phase, saponite, with up to 90% aluminum in tetrahedral configuration. In comparison, the use of a gel precursor resulted in a product with only 60% aluminum in the tetrahedral configuration. The synthesis temperature had no significant effect on the saponite structure. The reported synthesis method showed the possibility of obtaining saponite with superior characteristics, in terms of crystallinity, surface acidity, and thermal stability compared to the natural mineral, even at 90°C, and thus with greater potential for industrial application.

Bentonite, biotite, illite, kaolin, muscovite, vermiculite and zeolite were acidified or alkalized with HCl orNaOH of concentrations 0.0, 0.1, 1.0 and 5.0 mole dm−3 at room temperature for 2 weeks and converted into Ca homoionic forms. Low-temperature nitrogen and room-temperature water-vapor adsorption-desorption isotherms were used to characterize the mineral pores of radii between 1 and 30 nm. Nanopore volumes, size distributions, average radii and fractal dimensions were calculated. Values calculated from the nitrogen isotherms differed from those derived from water-vapor data. With an increase of the acid-treatment concentration, the pore volumes measured using both adsorption techniques increased markedly for all minerals. The pore radii measured from nitrogen isotherms appeared to decrease for all minerals except zeolite, while the pore radius calculated from water-vapor data increased in most cases. The fractal dimension measured from water vapor isotherms decreased in all cases indicating smoothing of the mineral surfaces and decrease in pore complexity. No well defined trends in any of the pore parameters listed above were noted under alkaline treatment. In the reaction of each mineral with acid and alkali treatments, the individual character of the mineral and the presence of impurities seems important.

Ziziphus lotus is an underappreciated natural genetic resource widespread in Algeria. This study aimed to compare the fruit phytochemical composition of nine populations of Z. lotus from different areas to highlight its diversity. Fruits were harvested from the semiarid, dry steppe and Saharan stages. Primary and secondary metabolites and minerals contents were determined. Significant variations in the fruit phytochemical composition between populations of Z. lotus and between pulp and seeds were recorded. Z. lotus is dry fruit with 8.768 ± 0.449 to 13.468 ± 1.303% water in pulp and 6.7 to 12.12% in seeds. Significantly higher values were recorded in the fruit pulp for sugar (35.25 to 48.87%), phosphorus (63.114 to 155.269 mg 100−1g), sodium (34.8 to 56.91 ppm), calcium (91.78 to 382.69 ppm), β-carotene (36.4 to 46 μg g−1), lycopene (59.15 to 100.25 μg g−1) and chlorophyll a (3.6 to 7.2 μg g−1) contents. Seeds had much higher protein (8.37 to 27.75%), lipid (35.39 to 48.01%), potassium (125.874 to 325.408 mg. 100−1 g), polyphenol (439.465 to 1349.46 mg.GAE.100 g−1), flavonoid (83.908 to 98.259 mg.QE.100 g−1), tannins (55.268 to 277.94 mg.GAE.100 g−1) and chlorophyll b (11.2 to 30.4 μg g−1) contents. Bougtob, Boghar and Mougheul populations had higher primary metabolites and mineral values. Oued Nougued, Maarif and Mougheul populations were the richest in phenolic compounds. Oued Nougued, Maarif and Mougheul populations had more liposoluble pigments. This research is the beginning of investigating the variety of Z. lotus as phylogenetic sources. Further comparative investigations over a larger distribution region and further study of variations in the composition in fruit composition using GC-MS are needed.

“Building Blocs” charts a global history of the last great crisis of globalization—the transwar decades from the 1880s through the 1940s—by centering strategic minerals needed to make steel. Little studied, but critically important, alloying minerals like tungsten and manganese were only needed in small amounts, but they were essential to the foundations of both national prosperity and security: steel and military production. Herein lay a fundamental problem: none of the industrial powers possessed adequate domestic deposits of these minerals, which were concentrated in remote locations such as central India, the Caucasus, southern China, Brazilian jungles, the Australian outback, and southern Africa. In a world in which steel was power, “Building Blocs” shows that resource anxieties motivated interwar quests for autarky and autonomy in the form of self-contained blocs. The scramble for strategic minerals escalated tensions and put rivals on the road to war, reshaping the forms and structures of geopolitical entities and international institutions throughout the transwar period.

This study is a comparative analysis of the biochemical, hormonal, and mineral compositions of follicular fluid in preovulatory and cystic follicles of water buffalo (Bubalus bubalis). In total, reproductive tracts from 215 buffalo along with intact ovaries were collected randomly from an abattoir. The incidence of cystic conditions found in this study was 3.72% (8/215), involving the right ovary in 62.5% of instances and the left ovary in 37.5% of instances during the non-breeding season. Follicular fluid was aspirated from preovulatory follicles (12–15 mm diameter, oestrogen-active, follicular phase or stage IV corpus luteum on one of the two ovaries, n = 10) and cystic follicles (at least 20 mm diameter, no corpus luteum on any one of the two ovaries, n = 8). The follicular fluid samples were assayed for biochemical components (uric acid, creatinine, blood urea nitrogen, cholesterol, total protein, glucose, ascorbic acid, and alkaline phosphatase), hormones (progesterone, estradiol, and insulin), and minerals (calcium, magnesium, phosphorus, copper, zinc, and cobalt). Cystic follicles had greater (P < 0.05) concentrations of creatinine, blood urea nitrogen, cholesterol, progesterone, copper, zinc, and cobalt, and lesser (P < 0.05) concentrations of uric acid, glucose, ascorbic acid, estradiol, insulin, calcium, magnesium, and phosphorus compared with preovulatory follicles. These results indicated the marked differences in follicular fluid composition between preovulatory and cystic follicles in buffalo. Some of the changes were indicative of oxidative stress and disturbed steroidogenesis, two important mechanisms shown to be associated with cystic ovarian disease in various species. Further studies are warranted to investigate whether these differences are directly or indirectly involved in the formation of cystic follicles or are mere manifestations of the condition.

The search for signs of life is a major objective in the exploration of Mars. Of particular interest are chemical biosignatures such as biomolecules. However, molecular biosignatures are susceptible to extreme environmental conditions such as heat, ionising radiation and strong oxidants. Therefore, a knowledge of the stability of possible biosignature molecules under present and past conditions on Mars is important, as well as the nature of possible alteration products. In the light of the long volcanically active history of Mars, we have studied the thermal behaviour of selected biological compounds, namely, haemin (an iron porphyrin closely related to the haem prosthetic group), cytochrome c (a small protein) and lecithin (a mixture of phospholipids). Samples were exposed to temperatures up to 900°C under an inert atmosphere of nitrogen, either in neat form or in mineral matrices. The matrix materials used were sodium chloride, gypsum (CaSO4 ⋅ 2H2O), Ca-montmorillonite (STx-1b), the Martian regolith simulant JSC Mars-1A and some mixtures thereof. Key results are: (1) The onset of significant decomposition for haemin, cytochrome c and lecithin occurs around 240°C. At slightly higher temperatures the disappearance of all characteristic infrared spectral bands indicates complete decomposition and loss of the primary biosignatures. (2) Haemin stoichiometrically releases CO2 and HCl during the initial thermal decomposition phase, at the end of which the iron porphyrin core is still intact. High-temperature products of haemin include graphite, α-iron and cementite (Fe3C). (3) Neat lecithin forms long-chain polyphosphates at 500°C, whereas lecithin‒NaCl mixtures form diphosphate (pyrophosphate). As these anions are absent and rare, respectively, in minerals, they may potentially serve as secondary biosignatures. (4) Heating a mixture of NaCl and JSC Mars-1A at 800°C in the presence of lecithin produces the aluminosilicate mineral sodalite (Na8[AlSiO4]6Cl2), which however appears to be of limited use as a secondary biosignature.

It is often stated that organic rice has a higher content of healthy phytochemicals than ordinary rice, and the facts on this claim obtained experimentally are rare. Riceberry is a new rice variety in Thailand. This study aimed to evaluate the effects of organic practice and conventional practice on the content of chemical composition and bioactive compounds in Riceberry rice. The results showed that agricultural practices were not significantly different for grain yield in the first year, but they were different in the second year. Rice produced by organic practice had a higher content of iron, gamma-aminobutyric acid, total phenolic and anthocyanin (4.15, 1.67, 41.3 and 20.1 mg/100 g dry weight in the first year, and 4.06, 3.37, 89.7 and 14.7 mg/100 g dry weight in the second year) than that produced by conventional practice (2.25, 1.11, 38.8 and 6.89 mg/100 g dry in the first year, and 1.96, 2.77, 54.1 and 5.71 mg/100 g dry in the second year). Rice produced by organic practice also had lower sugar content (2.92 g/100 g dry weight in the first year, and 1.99 g/100 g dry weight in the second year) than that produced by conventional practice (3.46 g/100 g dry weight in the first year, and 2.81 g/100 g dry weight in the second year). Gamma oryzanol and antioxidant capacity were also lower in organic rice compared to conventional rice. This study indicated that organic Riceberry rice had a higher quality compared to non-organic rice.

The percentage of US adults following low-carbohydrate diets (LCD) doubled in the last decade. Some researchers observed this trend with concern and highlighted the potential for nutritional deficiencies and impaired overall diet quality with LCD. The present study investigated nutrient intake in a nationally representative sample of 307 US adults following an LCD. Using cross-sectional data from the National Health and Nutrition Examination Surveys, we compared nutrient intake profiles in said individuals with the daily nutritional goals specified in the current 2020–2025 Dietary Guidelines for Americans (DGA). Results were then compared with the general population consuming a standard American diet. Almost 57 % of low-carbohydrate dieters were female, and the mean age was 48·67 (1·35) years. Individuals consuming LCD exceeded the recommendations for saturated fat, total lipid and sodium intake (both sexes). An insufficient intake was observed for fibre, Mg, potassium and several other vitamins (vitamins A, E, D in both sexes as well as vitamin C in men and folate in women). Neither men nor women met the recommendations for fibre intake. A comparable picture was found for the general population. The potentially insufficient intake of several essential nutrients in LCD warrants consideration and a careful assessment with regard to the current DGA.

This study aimed to conduct a meta-analysis based on a random-effects model to combine different published heritability estimates and genetic correlations for milk and serum minerals in dairy cows. In total, 59 heritability and 25 genetic correlation estimates from 12 articles published between 2009 and 2021 were used. The heritability estimates for milk macro-minerals were moderate to high and ranged from 0.311 (for Na) to 0.420 (for Ca). On the other hand, milk micro-minerals had lower heritabilities with a range from 0.013 (for Fe) to 0.373 (for Zn). The heritability estimates for serum macro-minerals were generally low and varied from 0.126 (for K) to 0.206 (for Mg). The estimates of genetic correlation between milk macro-minerals varied from −0.024 (between Na and K) to 0.625 (between Mg and P). The genetic correlations of milk Ca and P with milk yield were −0.171 and −0.211, respectively. The estimates of genetic parameters reported in this meta-analysis study are appropriate to utilize in breeding plans when valid estimates are not available for milk minerals in dairy cow populations.

Declining nutrient densities of crops in the past 50–70 years have been attributed to unsound agricultural practices and plant breeding focus on yield rather than quality. Few studies have quantified the soil and nutritional quality of grains in organic and conventional farms and reported results are scarce and inconsistent. The Rodale Institute's Farming Systems Trial (FST) was established in 1981 to quantify the effects of long-term organic and conventional grain cropping systems and tillage practices. A 2014 study to quantify effects on the nutrient density of oat grains was integrated into three systems within the long-term trial: organic manure-based (MNR), organic legume-based (LEG), and conventional synthetic input-based (CNV), split between tilled (T) and no-till (NT) practices. Oat grains with hulls removed were analyzed for minerals (n = 24), vitamins (n = 24), amino acids (n = 24) and proteins (n = 24), while soil samples to a depth of 10 cm were analyzed for elemental minerals, and total carbon (C), nitrogen (N) and sulfur (S). Organic systems increased six out ten soil minerals whose concentrations were influenced by cropping systems: aluminum (Al), iron (Fe), chromium (Cr), calcium (Ca), barium (B) and strontium (Sr). All essential amino acids were greater in oat grains under LEG systems compared with other systems except lysine, histidine and methionine. Both LEG systems also increased 12 out of 13 non-essential amino acids in oat grains. Total oat N, C and S required for amino acid synthesis tended to be greater in organic systems. Soil N, C and S were highly correlated with total oat amino acids under organic systems compared to CNV. Organic LEG had significantly greater vitamin B1 than MNR and CNV. These results suggest that nutrient concentrations of oat grains were greater in organic systems compared to CNV systems, and the increase could be partially explained by the long-term soil management differences between the systems.

Many persons with spinal cord injury (SCI) have one or more preventable chronic diseases related to excessive energetic intake and poor eating patterns. Appropriate nutrient consumption relative to need becomes a concern despite authoritative dietary recommendations from around the world. These recommendations were developed for the non-disabled population and do not account for the injury-induced changes in body composition, hypometabolic rate, hormonal dysregulation and nutrition status after SCI. Because evidence-based dietary reference intake values for SCI do not exist, ensuring appropriate consumption of macronutrient and micronutrients for their energy requirements becomes a challenge. In this compressive review, we briefly evaluate aspects of energy balance and appetite control relative to SCI. We report on the evidence regarding energy expenditure, nutrient intake and their relationship after SCI. We compare these data with several established nutritional guidelines from American Heart Association, Australian Dietary Guidelines, Dietary Guidelines for Americans, Institute of Medicine Dietary Reference Intake, Public Health England Government Dietary Recommendations, WHO Healthy Diet and the Paralyzed Veterans of America (PVA) Clinical Practice Guidelines. We also provide practical assessment and nutritional recommendations to facilitate a healthy dietary pattern after SCI. Because of a lack of strong SCI research, there are currently limited dietary recommendations outside of the PVA guidelines that capture the unique nutrient needs after SCI. Future multicentre clinical trials are needed to develop comprehensive, evidence-based dietary reference values specific for persons with SCI across the care continuum that rely on accurate, individual assessment of energy need.