Cities play a crucial role in green transformation and need strategies to address environmental, social and cultural issues. This article explores how Nature-Based Solutions (NBS) contribute to strengthening urban resilience, restoring biodiversity, improving air and water quality, and adapting to climate change. The integration of natural solutions with renewable energy systems and circular economy strategies reduces greenhouse gas emissions, enhances energy efficiency, strengthens resource resilience, and supports public health and economic stability. Important EU initiatives such as the Mission ‘100 Climate-Neutral and Smart Cities’, the Mission ‘Adaptation to Climate Change’, and the New European Bauhaus, provide a framework for integrating sustainability, inclusiveness and aesthetics into urban development. Technological concepts such as Digital Twins and Building Information Modelling help to adapt these innovations to local contexts. Examples of European cities (such as Barcelona Super Block, Aspern Smart City, Rotterdam hydrogen-fuel transport, etc.) clearly demonstrate benefits such as reduced emissions, increased biodiversity, and improved quality of life. This article underscores the role of interdisciplinary collaboration, innovation labs, and creative funding in advancing inclusive, climate-resilient urban transformation across Europe.