This study investigates the place of San Salvatore in the holy topography of Venetian Candia. By focusing on the largest convent in the Augustinian Province of the Holy Land, it contributes to a better understanding of a neglected subject in mendicant scholarship, namely the Augustinian friars’ expansion in the eastern Mediterranean. This article offers a detailed reconstruction of the demolished building and its sacred space, and sheds new light on interaction among the mixed Latin-Greek population in Venetian Crete by examining icons, altars, liturgy and, in particular, the introduction of the cult of Nicholas of Tolentino.