This study was conducted to identify the challenges faced by medical rescue teams during the response phase of sudden-onset disasters and provide a comprehensive understanding of these challenges. Peer-reviewed, English-language articles published until January 2023 that described the challenges faced by medical rescue teams during disaster response were searched in the Web of Science, Scopus, Cochrane, PubMed, and Science Direct databases. The articles were assessed using the Mixed Methods Appraisal Tool (MMAT) version 2018, a quality evaluation tool, and a qualitative thematic synthesis approach was adopted. A total of 353 publications were identified, and 18 of these met the inclusion criteria. Of the 18 included studies, 8 were review articles, 4 were special reports, 3 were cross-sectional studies, 1 was a mixed methods study, 1 was a qualitative study, and 1 was a short communication. Through qualitative analysis, the challenges faced by medical rescue teams during disaster response were categorized into 6 factors: organizational, individual, environmental and health, logistical, communication and information, and other factors. These factors are significant in terms of issues such as delayed access to disaster victims, disruptions in response processes, and an increase in morbidity and mortality rates. Therefore, the findings in our study shed light on future research in the field of disasters and offer opportunities to develop a roadmap for improving the conditions of medical rescue teams.

Antihistamines are among the most widely used medications in the world. Ebastine is an antihistaminic which is long-acting, second-generation, and selective H1-receptor inverse agonist. I report a twelve-year-and-six-month-old girl with temporary prolongation of the QTc interval caused by acute ebastine intoxication due to TikTok challenge. Initial electrocardiogram showed sinus arrhythmia (72 beats/min) and prolongation of the QTc interval (QTc 482 milliseconds). Gastric lavage was performed. Intravenous fluid was administered, and activated charcoal (1 g/kg/per dose) was given. Electrocardiogram 9 h after drug ingestion showed sinus rhythm and normal QTc interval (QTc 414milliseconds). During follow-up, no electrocardiogram abnormalities were detected with electrocardiogram monitoring. She was discharged on day 2 without any complications. This case report is the first in the literature to show acute intoxication with ebastine due to challenge video on TikTok, which leads to a temporary prolongation of the QTc interval. Also, with this case report, I assert the fact that it is important to properly supervise the use of social media, such as TikTok and to review the content of TikTok videos.

Drawing upon the thriving at work and agism literature, we added unexplored thriving antecedents (i.e., negative age-based metastereotypes and associated reactions) to the thriving nomological network. Additionally, we investigated the thriving-turnover intentions link throughout the lifespan. Parallel multiple mediator models were used to analyze the role played by threat and challenge in the relationship between negative age-based metastereotypes and overall thriving. Survey results (n = 326 employees) showed that threat and challenge mediated this relationship, yet differential relationships between antecedents and thriving appeared when analyzing thriving dimensions (i.e., learning and vitality) separately. Relatedly, turnover intentions were negatively predicted by overall thriving, but learning and vitality effects on turnover intentions were distinct across age groups. Findings recommend a clearer distinction between thriving dimensions role in the thriving experience throughout the lifespan. Overall, this study contends that the combination of thriving and agism literature contributes to further understand employee growth.

Infection with Eimeria sp. results in the activation of multiple facets of the host immune system; the use of phytogenics can modulate the inflammatory response and improve the performance of the challenged animal. The aim of this study was to evaluate the effect of a commercial blend of cashew nut shell liquid (CNSL) and castor oil on the immune response of broilers challenged with coccidiosis. A total of 864 one-day-old male chicks (Cobb 500) were randomly distributed into six treatment groups (8 pens/treatment and 18 chicks/pen) in a three-by-two factorial design with three additives: control (non-additive), 100 ppm of monensin or 0.15% CNSL–castor oil. Challenge status was determined twice at 14 days of age. Unchallenged birds were inoculated by gavage with oocysts sporulated with Eimeria tenella, Eimeria acervulina and Eimeria maxima. Although the positive control (non-additive and challenged) and CNSL–castor oil treatment groups exhibited similar variation in weight gain (ΔBWG) compared to unchallenged birds fed without additives, the variation observed in birds fed diets containing CNSL–castor oil was associated with a higher maintenance requirement and not feed efficiency. In the second week after infection, ΔBWG of the CNSL–castor oil treatment group did not significantly change compared to the other treatment groups. At days 7 and 14 post-challenge, there was a higher excretion of oocysts in the control group, whereas the CNSL–castor oil and monensin groups did not differ. The CNSL–castor oil group exhibited increased gene expression of interferon (IFN), interleukin 6 (IL-6) and tumor necrosis factor (TNF), while the control group exhibited increased expression of cyclooxygenase (COX) and IL-1. The heterophils/lymphocyte ratio was low for the monensin treatment group. The unchallenged birds that received monensin treatment presented higher gene expression of IFN, COX and IL-1 compared to the other treatments, while the CNSL–castor oil group exhibited reduced gene expression, except for TNF. The commercial blend of cashew nut liquid and castor oil modulated the inflammatory response against Eimeria spp. In the absence of the parasite, there was no stimulation of genes involved in the inflammatory response, demonstrating that the blend is an effective tool in specifically modulating the immune system of birds afflicted with coccidiosis.

The concept of épreuve, literally translated as ‘challenge’, was developed by the French sociologist Danilo Martuccelli, who was inspired by Sartre's existential philosophy, phenomenological sociology and its concern for analysing modern experiences, and Charles Wright Mills’ conviction that it is necessary to relate personal problems to the social structures that generate or amplify them. The concept has been used in the sociology of ageing in France to characterise the épreuve of ageing and four domains of épreuve have been identified: activities, identity, autonomy and relationship to the world. This paper applies this template to a corpus of 27 interviews with people at mild to moderate stages of Alzheimer's disease, in order to characterise the épreuve of ageing with the disease. The épreuve of ageing during the earlier stages of the disease is similar to the experience of people who age without a cognitive disorder. However, as the disease progresses the analysis reveals that it tends to exacerbate issues: identity seems especially threatened, simultaneously raising the question of self-presentation and self-definition; although most interviewees strive to retain autonomy, a few delegate it to a close confidante with whom they build a relationship of strong dependence; and weakened communication accentuates the feeling that the world is foreign and strange.

Has China been a hegemonic challenge to the United States in Latin America in recent years? The article explores this question by setting a comparison with historical cases of instances of hegemonic challenge in Latin America, searching for similarities and differences, and looking for makers of rivalry as a way to start to distinguish perception from reality. I stress the instrumentality of framing issues, since they serve for internal mobilization and for control of allies. The article also attempts to illuminate the issue of how the United States has reacted to China's growing presence in an area historically considered within its sphere of interests, or “backyard,” and about the dialogue between the United States and China about the region. It provides insights on the United States, China and Latin American countries’ policy makers’ thinking, collected through off-the- record interviews and closed-door debriefings.

The recent development of analytical models of trypanosomiasis has increased the general applicability of models to the strategic control of the disease. An analysis of detailed data on tsetse abundance and infection rates and trypanosome prevalence in village-based trypanotolerant cattle over 4 years in The Gambia showed that seasonal patterns of abundance in Glossina morsitans-infested areas were consistent, and that the rates of trypanosome infection remained relatively unchanging. However, there were two distinct seasonal trypanosome prevalence patterns in cattle, with peaks occurring either in May/June/July or November/December. The peaks of trypanosome prevalence therefore occurred either 4 months before or after the times of peak challenge from G. morsitans, not 1 or 2 months after as predicted by analytical models. In G. palpalis-infested areas there was little seasonal variation in abundance or trypanosome infections, but peak trypanosome prevalence still occurred mostly in June/July. Despite the incongruity between the months of peak prevalence and challenge, the overall annual prevalence rates and tsetse challenge indices showed a significant linear relationship. It is concluded that existing analytical models need to be refined to take into account trypanotolerance and the various influences on the expression of this trait.

The severity of the trypanosomiasis problem in a particular location is traditionally assessed in terms of a challenge index – the product of some measure of tsetse abundance and infection rate – which is assumed to be proportional to the force of infection. However, this index masks variation in the force of infection between herds and among individuals within herds. It is also not comparable between sites since the relative abundance of tsetse to hosts may vary. We have studied spatial distribution of herds of cattle in relation to tsetse in The Gambia and calculated an index of challenge based on the ratio of vectors to hosts over the livestock ranging area. This index is strongly correlated with estimates of the force of infection calculated from the incidence of infection in susceptible zebu; and it provides information on heterogeneity in exposure of different herds to tsetse.