We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Substance use refers to the consumption of drugs that have varying degrees of impact on a persons’ physical, mental and emotional well-being. While the adverse health effects of drugs have been extensively documented, further research is needed to understand their impact on fertility. Studies have indicated that substance use affects both the male and female reproductive systems. As substance use is more prevalent among young adults compared with the elderly, it appears that individuals of reproductive age are particularly vulnerable to the reproductive impairments associated with substance use. Although numerous studies have reported detrimental effects of substance use on pregnant women and their foetus during the post-implantation stages, there are limited studies on critical pre-implantation period and gamete stages. In this narrative review, we aimed to focus on the most significant evidence regarding the impact of substances on gametes and pre-implantation embryos.
‘Concepts and Universals in Aristotle’s Metaphysical Thought’ by Christof Rapp starts with the recognition that Aristotle does not have a general term for ‘concept’ and examines which entities in his metaphysical theory might play the role of concepts. According to Rapp, many of Aristotle’s discussions focus on the meaning of general terms and whether they signify something real and existing independently in its own right. Aristotle remains committed to the view that universals as captured by genuine definitions are crucial for human knowledge and understanding. Insofar as Aristotle resists a conception of universals as existing in the way that particular substances do, he can be taken to intimate that universals are ‘merely conceptual’. In the Metaphysics, he distances himself from the view that universals such as genera and species qualify as substances. His main contribution to our thinking about concepts consists in the view that both universals and embodied substantial forms have mental counterparts, by which we grasp and understand the things falling under the conceived form or essential definition.
It is relatively well known that Buridan’s nominalist semantics changed “the rules of the game” in practically all fields of philosophy and science. For instance, in his semantics, the traditional distinction between essential and accidental predicates is mapped onto the Ockhamist distinction between absolute and connotative terms and concepts. It is, however, still not quite well understood what impact these “new rules” had in particular philosophical disciplines. This essay offers a case study of the late-medieval paradigm change brought about by nominalist “semantical innovations.” In particular, it contrasts Aquinas’ “semantics-driven mereology” with Buridan’s, set against the background of Buridan’s new, nominalist semantics, arguing that the two authors’ differences in their mereological considerations are rooted in the differences between their diverse semantic intuitions. The conclusion of the essay will provide a brief logical and historical evaluation of the paradigmatic changes brought about by these diverse intuitions.
This chapter provides the volumes general conceptual framework. It begins by addressing why new approaches to accountability are needed, arguing that accountability literature has reached a stalemate as a result of an impasse between deductive and inductive approaches to accountability in the EU. It then argues that overcoming the stalemate requires developing a generalised framework of what accountability is for, deriving four accountability goods to be used in subsequent chapters. The chapter argues that each of the goods can be delivered in procedural or substantive ways, focusing either on the process by which decisions are made or the substantive worth of decisions themselves. The chapter concludes by discussing the strengths and weaknesses of both varieties of accountability before mapping out how the concepts will be applied across policy fields and institutions in subsequent chapters.
We aimed to investigate child mortality, perinatal morbidities and congenital anomalies born by women with substance misuse during or before pregnancy (DP or BP).
Methods
Taiwan Birth Registration from 2004 to 2014 linking Integrated Illicit Drug Databases used to include substance misuse participates. Children born by mothers convicted of substance misuse DP or BP were the substance-exposed cohort. Two substance-unexposed comparison cohorts were established: one comparison cohort selected newborns from the rest of the population on a ratio of 1:1 and exact matched by the child’s gender, child’s birth year, mother’s birth year and child’s first use of the health insurance card; another comparison cohort matched newborns from exposed and unexposed mothers by their propensity scores calculated from logistic regression.
Results
The exposure group included 1776 DP, 1776 BP and 3552 unexposed individuals in exact-matched cohorts. A fourfold increased risk of deaths in children born by mothers exposed to substance during pregnancy was found compared to unexposed group (hazard ratio [HR] = 4.54, 95% confidence interval (CI): 2.07–9.97]. Further multivariate Cox regression models with adjustments and propensity matching substantially attenuated HRs on mortality in the substance-exposed cohort (aHR = 1.62, 95% CI: 1.10–2.39). Raised risks of perinatal morbidities and congenital anomalies were also found.
Conclusions
Increased risks of child mortality, perinatal morbidities or congenital anomalies were found in women with substance use during pregnancy. From estimates before and after adjustments, our results showed that having outpatient visits or medical utilizations during pregnancy were associated with substantially attenuated HRs on mortality in the substance-exposed cohort. Therefore, the excess mortality risk might be partially explained by the lack of relevant antenatal clinical care. Our finding may suggest that the importance of early identification, specific abstinence program and access to appropriate antenatal care might be helpful in reducing newborn mortality. Adequate prevention policies may be formulated.
There is evidence for intergenerational transmission of substance use and disorder. However, it is unclear whether separation from a parent with substance use disorder (SUD) moderates intergenerational transmission, and no studies have tested this question across three generations. In a three-generation study of families oversampled for familial SUD, we tested whether separation between father (G1; first generation) and child (G2; second generation) moderated the effect of G1 father SUDs on G2 child SUDs. We also tested whether separation between father (G2) and child (G3; third generation) moderated the effect of G2 SUDs on G3 drinking. Finally, we tested whether G1-G2 or G2-G3 separation moderated the mediated effect of G1 SUDs on G3 drinking through G2 SUDs. G1 father-G2 child separation moderated intergenerational transmission. In families with G1-G2 separation, there were no significant effects of father SUD on G2 SUD or G3 drinking. However, in nonseparated families, greater G1 father SUDs predicted heightened G2 SUDs and G3 grandchild drinking. In nonseparated families, G1 father SUDs significantly predicted G2 SUDs, which predicted G3 drinking. However, G2-G3 separation predicted heightened G3 drinking regardless of G2 and G1 SUDs. Parental separation may introduce risk for SUDs and drinking among youth with lower familial risk.
The idea of a material constitution has become influential for at least two reasons. The first reason is the absence of coincidence between the scope of the rules of the formal or written constitution and the wider field of constitutional rules. Second, the idea of a material constitution also comes into play as some authors will define the constitution by a specific content or ’matter’. This chapters aims at clarifying the uses of the reference to a constitutional matter by exploring the form versus matter distinction. The core of our case can be summed up as follows: the form of the constitution is law; the matter of the constitution is politics. Politics, as a social activity, influences law as much as law, in turn, can govern political action to a certain degree. In this process, legal substance is as relevant as legal form. What matters, thus, is a relative degree of fitness between political activity (or matter) and law. A (sufficiently) ’good’ constitution allows for political activity to take place, while shaping it in keeping with basic constitutionalist values and principles. Such a constitution can be defined as a principled instrument of self-government.
This chapter introduces the two main questions that this book attempts to answer. First: Why powers? Second: What are powers like? It also discusses the overlap between metaphysics and science, some differences between powers and qualities, the relationship between properties and substances, how we can know powers, and different types of powers isms. The chapter then distinguishes between networking and nodal accounts of powers before previewing the central idea of the book: the 3d account of powers (a nodal account), which combines two core theses. The first is the Physical Intentionality Thesis, which concerns the fact of physical intentionality: that the power is directed toward manifestations. The second is the Informational Thesis, which concerns the content of physical intentionality: what the power is for or directed toward. Lastly, a roadmap for the rest of the book is provided.
Substance has long been one of the key categories in metaphysics. This Element focuses on contemporary work on substance, and in particular on contemporary substance ontologies, metaphysical systems in which substance is one of the fundamental categories and individual substances are among the basic building blocks of reality. The topics discussed include the different metaphysical roles which substances have been tasked with playing; different critieria of substancehood (accounts of what is it to be a substance); arguments for and against the existence of substances; and different accounts of which entities, if any, count as substances.
This chapter examines the relationship between “logic,” language, and methodology in Heidegger. It begins by contrasting two ways in which one might understand that relationship: Dummett’s position as articulated in The Logical Basis of Metaphysics and Dreyfus’s influential reconstruction of Sein und Zeit. Focusing on Sein und Zeit §33, the chapter distinguishes Heidegger’s own view from each of these. First, drawing on his discussions of “grammar,” it shows where and why he diverges not just from someone like Dummett, but also from Kant. Second, it argues for the difference between the approach in this chapter and the Dreyfusian one: For Dreyfus, Heidegger’s attack on logic is ultimately a question of content, for Golob it is ultimately a question of method. The chapter closes by indicating how this analysis might be extended to texts from the 1924 Platon: Sophistes lectures to Die Sprache in the 1950s, paying particular attention to the concept of a “meta-language.”
The prevalence of substance use disorder has rapidly increased recently. It is believed that the occurrence of mental disorders is strongly associated with substance use.
Objectives
To identify prevelance of different psychiatric mobidity & symptomatology as Comorbidity amon the diagnosed patients of Substance Use Disorder
Methods
This study was conducted from June till December 2021. A total of 486 PDUs were recruited for this study. A self-administered questionnaire was distributed among PDUs admitted at the Rehabilitation Centre during the period of the study. The questionnaire inquired about the demographic details of the PDUs, their substance history and the occurrence of any MDs.
Results
The mean age of the PDUs was 25.9 + 6.0 years. A total of (95%) men and (5%) women reported their gender. There were single (74.7%), married (23.1%), divorced (1.4%) and separated (0.7%) PDUs. A large majority of the PDUs (n = 159, 55.6%) had been using different drugs for more than three years. The various MDs reported among the PDUs were delusion (n = 100, 35.2%); paranoia (n = 51, 17.8%); mania (n = 36, 12.6%); depression (n = 156, 54.5%); (n = 100, 35.2%); auditory hallucinations (n = 73, 25.7%); visual hallucinations (n = 106, 37.3%) and anxiety (n = 46, 16.2%). Among 164 cannabis users, hallucinations (n = 35, 21.3%; p = 0.04) was the only significant MD.
Conclusions
Delusion and paranoia were amongst the most highly prevalent MDs reported. The occurrence of auditory hallucinations, mania and paranoia were significantly associated with cannabis, heroin and cocaine use, respectively.
Given the evidence that drinking patterns and self-harm hospital presentations have changed during COVID-19, this study aimed to examine any change in self-harm and suicide-related ideation presentations, together with any possible contribution made by alcohol or substance misuse, to Irish Emergency Departments in 2020, compared with 2018 and 2019.
Methods:
A population-based cohort with self-harm and suicide-related ideation presenting to Irish hospitals derived from the National Clinical Programme for Self-Harm was analysed. Descriptive analyses were conducted based on sociodemographic variables and types of presentation for the period January to August 2020 and compared with the same period in 2018 and 2019. Binomial regression analyses were performed to investigate the independent effect of demographic characteristics and pre/during COVID-19 periods on the use of substances as contributory factors in the self-harm and suicide-related ideation presentations.
Results:
12,075 presentations due to self-harm and suicide-related ideation were recorded for the periods January–August 2018–2020 across nine emergency departments. The COVID-19 year was significantly associated with substances contributing to self-harm and suicide-related ideation ED presentations (OR = 1.183; 95% CI, 1.075–1.301, p < 0.001). No changes in the demographic characteristics were found for those with self-harm or suicide-related ideation across the years. Suicide-related ideation seemed to be increased after May 2020 compared with previous years. In terms of self-harm episodes with comorbid drug and alcohol overdose and poisoning, these were significantly increased in January–August 2020, compared with previous timepoints (χ2 = 42.424, df = 6, p < 0.001).
Conclusion:
An increase in suicide-related ideation and substance-related self-harm presentations may indicate longer term effects of the pandemic and its relevant restrictions. Future studies might explore whether those presenting with ideation will develop a risk of suicide in post-pandemic periods.
Psychological science constructs much of the knowledge that we consume in our everyday lives. This book is a systematic analysis of this process, and of the nature of the knowledge it produces. The authors show how mainstream scientific activity treats psychological properties as being fundamentally stable, universal, and isolable. They then challenge this status quo by inviting readers to recognize that dynamics, context-specificity, interconnectedness, and uncertainty, are a natural and exciting part of human psychology – these are not things to be avoided and feared, but instead embraced. This requires a shift toward a process-based approach that recognizes the situated, time-dependent, and fundamentally processual nature of psychological phenomena. With complex dynamic systems as a framework, this book sketches out how we might move toward a process-based praxis that is more suitable and effective for understanding human functioning.
These remarks focus on Kraus’s claim that for Kant the category of substance cannot apply to the soul but that instead we can and should apply a merely regulative idea of the soul. While granting Kraus’s contention that we require an idea of the soul in order to investigate inner experience, I argue that the category of substance nonetheless applies to the soul, but that the notion of the soul as entirely non-corporeal is a regulative idea. To explore this contention, I closely examine two crucial passages Kraus uses to argue against parity between inner and outer sense.
Bartolus of Sassoferrato, the leading jurist of his day, whose influence spanned several centuries, first formulated an equation of family and its property (substantia) that cast an image of family enduring over time in the immediate passage of property from father to son. That tie was so pivotal that a son could be termed, however incorrectly in strict legal terms, as a co-owner of the estate with his father. Disinheritance was difficult to conceive of in these terms, although it was an allowed legal institution. Subsequent jurists followed Bartolus's lead, even though they were likely to face only situations where the paradigmatic passage of haereditas from father to son was not possible.
In late medieval and Renaissance Italian societies, family was conceived as a quasi-corporate entity, continuing across generations. But in law ownership was conceived as an attribute of individuals, and generally of only one person in a household, the paterfamilias. Legal experts worked to accommodate legal notions to the realities of family life, which were close to what anthropologists have come to term an economy of sharing (with multiple and overlapping rights). Law thus came to provide instruments that helped perpetuate families or terminate them. It fell to the paterfamilias to manage property and use legal instruments to do so in order that the patrimony, substantia, could be transmitted to the next generation.
Behavioural couples therapy (BCT) and alcohol behavioural couples therapy (ABCT) are couples-based interventions for substance use disorders (SUDs) that have been deemed a ‘gold standard’ treatment. Despite the substantial amount of promising research, there is a lack of research on the active components of treatment and treatment mechanisms and moderators. Since the most recent meta-analysis, a number of studies have been conducted that advance our understanding of the efficacy of BCT and ABCT.
Aims:
The purpose of the present review was to provide an update on the current knowledge of these treatments and to investigate mediators and moderators of treatment.
Method:
A systematic search strategy of relevant databases from 2008 to 2021 identified 20 relevant articles that were coded for relevant information including study design, treatment, outcomes, as well as mechanisms and moderators.
Results:
The results indicated that BCT and ABCT are successful in reducing alcohol and substance use for both male and female clients, dual problem couples, and for reducing post-traumatic stress symptoms and intimate partner violence. The reviewed studies discussed a number of treatment mechanisms, with the most studied mechanism being relationship functioning. Moderators included relationship functioning and patient gender.
Conclusions:
The results point to the need for additional research on active treatment components, mechanisms and moderators, in order to provide a more efficient and cost-effective treatment.
This chapter concerns the early modern redefinition of psychology as the science of mind. It examines the way the “invention of mind” was incorporated into Descartes’s metaphysical project. This Cartesian innovation marked a rupture from the traditional science of the soul as a division of natural science or physics. Rejecting the Aristotelian partition of the soul into distinct powers and the Scholastic view of the principle of thought (the intellect) as only the highest psychic power, the new Cartesian psychology required the unity of the soul as the thinking substance. What constituted early modern psychology as a metaphysical science of mind, this chapter argues, was fundamentally Descartes’s “realist” thesis that mind is a thing (res). Together with this Cartesian substantialist view, its critical reception structured the modern science of mind. The early modern alternatives to Descartes’s ontological thesis about mind, the chapter highlights, were based either on the argument that mind is not a thing or on the argument that mind is a non-substantial thing, a mere mode. The chapter illustrates the first argument with Hobbes, the second with Regius and Spinoza.
The way Leibniz applied his philosophy to mathematics has been the subject of longstanding debates. A key piece of evidence is his letter to Masson on bodies. We offer an interpretation of this often misunderstood text, dealing with the status of infinite divisibility in nature, rather than in mathematics. In line with this distinction, we offer a reading of the fictionality of infinitesimals. The letter has been claimed to support a reading of infinitesimals according to which they are logical fictions, contradictory in their definition, and thus absolutely impossible. The advocates of such a reading have lumped infinitesimals with infinite wholes, which are rejected by Leibniz as contradicting the part–whole principle. Far from supporting this reading, the letter is arguably consistent with the view that infinitesimals, as inassignable quantities, are mentis fictiones, i.e., (well-founded) fictions usable in mathematics, but possibly contrary to the Leibnizian principle of the harmony of things and not necessarily idealizing anything in rerum natura. Unlike infinite wholes, infinitesimals—as well as imaginary roots and other well-founded fictions—may involve accidental (as opposed to absolute) impossibilities, in accordance with the Leibnizian theories of knowledge and modality.
Substance (substantia, zelfstandigheid)’ is a key term of Spinoza’s philosophy. Like almost all of Spinoza’s philosophical vocabulary, Spinoza did not invent this term, which has a long history that can be traced back at least to Aristotle. Yet, Spinoza radicalized the traditional notion of substance and made a very powerful use of it by demonstrating – or at least attempting to demonstrate – that there is only one, unique substance – God (or Nature) – and that all other things are merely modes or states of God. In the first section, I examine Spinoza’s definitions of "substance" and "God" at the opening of the Ethics. In the second section, I study the properties of the fundamental binary relations pertaining to Spinoza’s substance: inherence, conception, and causation. The third section is dedicated to a clarification of Spinoza’s claim that God, the unique substance, is absolutely infinite. The fourth section studies the nature of Spinoza’s monism. It will discuss and criticize the interesting yet controversial views of Martial Gueroult, about the plurality of substances in the beginning of the Ethics and evaluate Spinoza’s kind of ontological monism. The fifth and final section explains the nature, reality, and manner of existence of modes.