Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-14T23:00:20.787Z Has data issue: false hasContentIssue false
  • English
  • Français

Refining the bigger picture: On the integrative memory model

Published online by Cambridge University Press:  03 January 2020

John P. Aggleton Open the ORCID record for John P. Aggleton [Opens in a new window]
John P. Aggleton*
Affiliation:
School of Psychology, Cardiff University, Cardiff, CF10 3AT, Wales, United Kingdom. aggleton@cf.ac.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

The integrative memory model contains multiple subsystems. In this commentary, the processes within these subsystems are questioned. First, the assumption that familiarity largely reflects perceptual fluency is examined. Next, the distinction between “process” and “representational” models of temporal lobe function is challenged. Finally, the “relational representation core system” (or “extended hippocampal system”), which is central to the model, is especially sketchy. Here, I highlight key questions to be addressed in order to understand this system's role in trace formation.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e282
Check for updates
Copyright
Copyright © Cambridge University Press 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aggleton, J. P. & Brown, M. W. (1999) Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behavioral and Brain Sciences 22:425–89.CrossRefGoogle ScholarPubMed
Aggleton, J. P. & Brown, M. W. (2006) Interleaving brain systems for episodic and recognition memory. Trends in Cognitive Sciences 10(10):455–63.CrossRefGoogle ScholarPubMed
Aggleton, J. P., O'Mara, S. M., Vann, S. D., Wright, N. F., Tsanov, M. & Erichsen, J. T. (2010) Hippocampal–anterior thalamic pathways for memory: Uncovering a network of direct and indirect actions. European Journal of Neuroscience 31(12):2292–307.CrossRefGoogle ScholarPubMed
Aggleton, J. P., Pralus, A., Nelson, A. J. & Hornberger, M. (2016) Thalamic pathology and memory loss in early Alzheimer's disease: Moving the focus from the medial temporal lobe to Papez circuit. Brain 139(7):1877–90.CrossRefGoogle ScholarPubMed
Carlesimo, G. A., Lombardi, M. G. & Caltagirone, C. (2011) Vascular thalamic amnesia: A reappraisal. Neuropsychologia 49(5):777–89.CrossRefGoogle ScholarPubMed
Dzieciol, A. M., Bachevalier, J., Saleem, K. S., Gadian, D. G., Saunders, R., Chong, W. K., Banks, T., Mishkin, M. & Vargha-Khadem, F. (2017) Hippocampal and diencephalic pathology in developmental amnesia. Cortex 86:33–44.CrossRefGoogle ScholarPubMed
Griffiths, S., Scott, H., Glover, C., Bienemann, A., Ghorbel, M. T., Uney, J., Brown, M. W., Warburton, E. C. & Bashir, Z. I. (2008) Expression of long-term depression underlies visual recognition memory. Neuron 58(2):186–94.CrossRefGoogle ScholarPubMed
Holscher, C., Rolls, E. T. & Xiang, J. (2003) Perirhinal cortex neuronal activity related to long-term familiarity memory in the macaque. European Journal of Neuroscience 18(7):2037–46.CrossRefGoogle ScholarPubMed
Jankowski, M. M., Passecker, J., Islam, M. N., Vann, S., Erichsen, J. T., Aggleton, J. P. & O'Mara, S. M. (2015) Evidence for spatially-responsive neurons in the rostral thalamus. Frontiers in Behavioral Neuroscience 9: article no. 256. Available at: https://www.frontiersin.org/articles/10.3389/fnbeh.2015.00256/full.CrossRefGoogle Scholar
Segobin, S., Laniepce, A., Ritz, L., Lannuzel, C., Boudehent, C., Cabe, N., Urso, L., Vabret, F., Eustache, F., Beaunieux, H. & Pitel, A. L. (2019) Dissociating thalamic alterations in alcohol use disorder defines specificity of Korsakoff syndrome. Brain 142(5):1458–70. doi.org/10.1093/brain/awz056.CrossRefGoogle Scholar
Tsivilis, D., Vann, S. D., Denby, C., Roberts, N., Mayes, A. R., Montaldi, D. & Aggleton, J. P. (2008) A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Nature Neuroscience 11(7):834–42. doi: 10.1038/nn.2149.CrossRefGoogle ScholarPubMed
Vann, S. D., Tsivilis, D., Denby, C. E., Quamme, J. R., Yonelinas, A. P., Aggleton, J. P., Montaldi, D. & Mayes, A. R. (2009b) Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods. Proceedings of the National Academy of Sciences 106(13):5442–47.CrossRefGoogle Scholar