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We expand the theory of 2-classifiers, that are a 2-categorical generalization of subobject classifiers introduced by Weber. The idea is to upgrade monomorphisms to discrete opfibrations. We prove that the conditions of 2-classifier can be checked just on a dense generator. The study of what is classified by a 2-classifier is similarly reduced to a study over the objects that form a dense generator. We then apply our results to the cases of prestacks and stacks, where we can thus look just at the representables. We produce a 2-classifier in prestacks that classifies all discrete opfibrations with small fibres. Finally, we restrict such 2-classifier to a 2-classifier in stacks. This is the main ingredient of a proof that Grothendieck 2-topoi are elementary 2-topoi. Our results also solve a problem posed by Hofmann and Streicher when attempting to lift Grothendieck universes to sheaves.
Reliable and specific biomarkers that can distinguish autism spectrum disorders (ASDs) from commonly co-occurring attention-deficit/hyperactivity disorder (ADHD) are lacking, causing misses and delays in diagnosis, and reducing access to interventions and quality of life.
Aims
To examine whether an innovative, brief (1-min), videogame method called Computerised Assessment of Motor Imitation (CAMI), can identify ASD-specific imitation differences compared with neurotypical children and children with ADHD.
Method
This cross-sectional study used CAMI alongside standardised parent-report (Social Responsiveness Scale, Second Edition) and observational measures of autism (Autism Diagnostic Observation Schedule-Second Edition; ADOS-2), ADHD (Conners) and motor ability (Physical and Neurological Examination for Soft Signs). The sample comprised 183 children aged 7–13 years, with ADHD (without ASD), with ASD (with and without ADHD) and who were neurotypical.
Results
Regardless of co-occurring ADHD, children with ASD showed poorer CAMI performance than neurotypical children (P < 0.0001; adjusted R2 = 0.28), whereas children with ADHD and neurotypical children showed similar CAMI performance. Receiver operating curve and support vector machine analyses showed that CAMI distinguishes ASD from both neurotypical children (80% true positive rate) and children with ADHD (70% true positive rate), with a high success rate significantly above chance. Among children with ASD, poor CAMI performance was associated with increased autism traits, particularly ADOS-2 measures of social affect and restricted and repetitive behaviours (adjusted R2 = 0.23), but not with ADHD traits or motor ability.
Conclusions
Four levels of analyses confirm that poor imitation measured by the low-cost and scalable CAMI method specifically distinguishes ASD not only from neurotypical development, but also from commonly co-occurring ADHD.
This article provides a snapshot of the Royal Carl Rosa Opera Company’s ‘Coronation’ tour in 1937, focusing particularly on the company’s time in Johannesburg. It considers the Carl Rosa’s tour as a ‘cultural colonisation’ endeavour on the part of the British Empire, aimed at reinforcing identity politics at a time when loyalty to the Empire was waning. The article examines the significance of the Carl Rosa’s tour within the broader context of British colonial relations and the Coronation celebrations of George VI in the Union. Central to its argument is the analysis of the tour’s commemorative programme, published by African Consolidated Theatres (ACT), which serves as a lens to understand the articulation of Dominion South Africanism amongst English-speaking audiences. Through an examination of primary sources and historical context, this article sheds light on the complexities of imperial encounters and the role of cultural exchange in perpetuating colonial power dynamics.
Particle-laden flow through conduits is ubiquitous in both natural and industrial systems. In such flows, particles often migrate across the main fluid stream, resulting in non-uniform spatial distribution owing to particle–fluid and particle–particle interactions. The most relevant lateral particle migration mechanism by particle–fluid interaction is the Segré–Silberberg effect, which is induced by the inertial forces exerted on a particle, as the flow rate increases. However, methods to suppress it have not been suggested yet. Here, we demonstrate that adding a small amount of polymer to the particle-suspending solvent effectively suppresses the Segré–Silberberg effect in a square channel. To accurately determine the position of the particles within the channel cross-sections, we devised a dual-view imaging system applicable to microfluidic systems. Our analyses show that the Segré–Silberberg effect is effectively suppressed in a square microchannel due to the balance between the inertial and elastic forces at an optimal polymer concentration while maintaining nearly constant shear viscosity.
Psychogenic pseudosyncope is one of the primary causes of transient loss of consciousness in children and adolescents, essentially classified as a conversion disorder that significantly impacts patients’ quality of life. Clinically, psychogenic pseudosyncope shares certain similarities with vasovagal syncope in terms of pre-syncope symptoms and triggers, making it sometimes difficult to differentiate and easily misdiagnosed. Therefore, placing emphasis upon the characteristics of psychogenic pseudosyncope is crucial for early identification and treatment, which holds significant importance for the mental and psychological health of children and adolescents. In the present review, we aimed to address psychogenic pseudosyncope with clinical features, diagnosis, and treatment.
As societies grapple with mitigating or adapting to climate change, law plays a prominent role in the social relations that constitute a response. In this essay, we briefly review of the many different perspectives on law and climate change offered by the authors in this special issue of Law and Society Review. From transnational human rights activism to constitutional litigation to local practices and all around the globe, both the powerful and the marginalized draw on legal institutions and actors in multiple arenas and at multiple scales to address the consequences of climate change. Together, these articles show that law is not confined to courtrooms or judicial systems or regulations; rather, law offers both limitations and opportunities in the ongoing struggle over climate change.
While conducting experiments via the Internet has become quite popular recently, there is still an ongoing debate regarding the reliability of data obtained using this method, especially for subtle manipulations and measurements susceptible to minor changes (e.g., reaction times). In this series of two experiments employing the emotional Stroop task (using emotional word stimuli differing in their valence, arousal, and subjective significance levels), we compared the reaction times of participants taking part in experiments either in the laboratory (Experiment 1) or online (Experiment 2). In line with previous studies, there were no significant differences observed between the two experiments. Both modes of conducting studies yielded a similar pattern of results, namely interactions between valence and arousal, and a three-way interaction between valence, arousal, and subjective significance. We conclude that the pattern of disturbance in cognitive processing caused by affect is not susceptible to the setting that the subjects are in, which may be a significant argument for reliability of affect-related experiments conducted online.
A patient with borderline left ventricle successfully underwent biventricular repair following a staged surgical approach to promote left ventricular growth. Despite initial concerns about left ventricle size, apex formation and adequate size of atrioventricular valve indicated potential for future growth. The patient demonstrated significant left ventricular growth, resulting in stable biventricular circulation and a favourable outcome over a three-year postoperative follow-up period.
Clinical Registration Number: Institutional Review Board of Osaka City General Hospital, number 1902139.
The Czechoslovak oppositional initiative Charter 77 produced dozens of documents on human rights between 1977 and 1992. Yet it never dedicated a separate document to women's rights, even if the issue of women's equality was well represented in global human rights discourse at the time. This article explores this absence in Charter 77's intellectual production. It analyses in detail several Charter documents and samizdat publications that touched upon issues of women's equality, showing that some Charter signatories were ready to acknowledge that the socialist state granted women formal equality, while suggesting that neither material conditions nor cultural norms provided full emancipation. However, a more prevalent critique marked the socialist agenda of women's emancipation as something that restricted women's individual freedom in their personal lives. I argue that in their legalistic approach, the Charter milieu largely lacked the conceptual tools to explore discrimination against women as the manifestation of the broader imbalance of power between men and women beyond the law.
The controllability of passive microparticles that are advected with the fluid flow generated by an actively controlled one is studied. The particles are assumed to be suspended in a viscous fluid and well separated so that the far-field Stokes flow solutions may be used to describe their interactions. Explicit elementary moves parametrized by an amplitude $\varepsilon >0$ are devised for the active particle. Applying concepts from geometric control theory, the leading-order resulting displacements of the passive particles in the limit $\varepsilon \to 0$ are used to propose strategies for moving one active particle and one or two passive particles, proving controllability in such systems. The leading-order (in $\varepsilon$) theoretical predictions of the particle displacements are compared with those obtained numerically and it is found that the discrepancy is small even when $\varepsilon \approx 1$. These results demonstrate the potential for a single actuated particle to perform complex micromanipulations of passive particles in a suspension.
Whether referendums, initiatives, and other mechanisms of direct democracy enhance representative systems is a matter of debate. Skeptics note—among other criticisms—that turnout tends to be low in referendums, often lower than in candidate elections in the same country. If citizens do not care enough to participate, how useful can these mechanisms be for improving the quality of democratic systems? We argue that low referendum turnout has as much to do with parties’ disincentives to mobilize voters as it does with voter disinterest. Prior research on political behavior in referendums has focused largely on Europe and assumes that voters view them as elections of lesser importance. By shifting focus to Latin America, we introduce more variation in the features of political parties that influence levels of turnout. We draw on cross-national evidence, qualitative research in Colombia, and quantitative analysis of municipal-level referendum voting behavior in Brazil. The key to understanding low voter turnout in these settings is the relatively weaker incentives that political parties have to turn out the vote when control over office is not at stake. We demonstrate that, in clientelistic systems, party operatives have particularly weak incentives to get their constituents out to the polls.
Designing effective language learning settings requires an understanding of the processes taking place in language learning and the way they interact. One important issue concerns the interaction between meaning and grammar. A number of studies have shown a beneficial effect of semantics in grammar learning. What is unclear, however, is how far this effect may be influenced by the presentation formats of the semantic content. In two experiments, participants performed rule search tasks on Latin sentences. In Experiment 1, we presented semantic information in the form of naturalistic photographs, whereas in Experiment 2, the semantic information was implemented by quasi-translations. The control groups did not receive any semantic information. Learning performance was assessed by a grammaticality-judgment task combined with a source-attributions task. In both experiments, participants in the with-semantics group outperformed the respective control groups. Yet, only in Experiment 1, participants report having more explicit than implicit knowledge. We argue that semantic information boosts the acquisition of grammatical structures regardless of the presentation format. Furthermore, we suggest that, consistent with multimedia learning theories, the pictorial presentation format of Experiment 1 helped to use working memory capacity efficiently, which may have led to the generation of more explicit knowledge.
Sudden cardiac death poses a significant risk in patients with surgically repaired tetralogy of Fallot. Despite extensive research, risk stratification practices vary. This study surveyed the Pediatric and Adult Congenital Electrophysiology Society to identify these differences. Results showed diverse practices in indications, methods, and interpretation of electrophysiology studies, highlighting a need for standardised algorithms to improve patient outcomes.
Since the 1990s, the Pro-Life Alliance of Gays and Lesbians (PLAGAL) has positioned sexual minorities and fetuses as alike in struggle. The lesbian, gay, and bisexual members of this relatively small organization argued that tolerance and inclusivity of their positionality were strategically beneficial to both the gay rights and antiabortion movements. Ultimately, PLAGAL failed to convince many of the “legitimacy” of their campaigns, and was repeatedly expelled from both right-to-life rallies and Pride marches. This notwithstanding, PLAGAL organizing reveals much about (the limits of) identity politics and the relationship of different social and political movements in this turbulent decade.
Widening and diversifying trade networks are often cited among the boom and bust of Bronze and Iron Age worlds. The great distances that goods could travel during these periods are exemplified here as the authors describe the spectroscopic identification of Baltic amber beads in an Iron Age cremation grave at Hama in Syria. Yet these beads are not unique in the Near Eastern record; as the authors show, comparable finds and references to amber or amber hues in contemporaneous texts illustrate the high social and economic value of resinous substances—a value based on perceptions of their distant origin.